The resistive economy policies, with its emphasis on cutting off dependencies and emphasizing on the benefits of production, strives for self-sufficiency, restructuring, and the revival of the national economy. In order to achieve a resistive economy it’s necessary to establish and create conditions and contexts that, which if not realized, one cannot expect to have a resistive economy in the country. One of the main approaches for achieving the goals of these policies is to reduce the dependence on commodity-based economy that can only be achieved through the strengthening the foundations of a knowledge-based economy in the country; therefore, the approach towards knowledge-based economy and proper execution of knowledge management in knowledge-based organizations and institutions helps the country to achieve this goal. The present study investigates the relationship between the effectiveness of a comprehensive knowledge management system on the components of resistive economy in a knowledge-based defensive company. For this purpose, after conducting extensive library and field studies using partial least squares method, questionnaire analysis and interview with experts in the fields of knowledge management and resistive economy, the relationship between the effectiveness of comprehensive knowledge management system on resistive economy components was evaluated and the model presented was evaluated and analyzed using Structural Equation Modeling (PLS) and AMOS software for the studied company. Results show that in this knowledge-based company, knowledge management has a positive and significant impact on the resistive economy components and this company can somehow indirectly assist the country in the realization of the resistive economy by investing in the knowledge management